If you have 40 bombs it will spawn 4 x Boom! While you have this flame you also have that item's effect, The flame deals double your tear damage to any enemies that touch it, but if it takes too much damage the flame will disappear and you lose the item's effect, Wisps are randomly chosen from Item Room, Boss Room and Shop item pools, with a 25% chance to pick the same pool as the current room. Generally every interaction and synergy that applies to Chemical Peel also applies to Blood Clot. Tears have a 50% chance to be Blood Clot tears. Effects. Rooms UNLOCK: Unlock this item by defeating Mother in the Corpse II as ??? He can pick up coins to restore health, Similar to other familiars of this kind, you can hold the drop key to cause him to stand still, If he dies, his corpse turns into a few blue spiders. The more items in a pool, the more likely that pool will be picked, A familiar grey spider that wanders around and allows you to see your tear damage and the health bars of all enemies, The spider will inflict a random status effect on any enemies it comes into contact with (e.g. ?? The Forgotten - Your Soul is now unchained and free to move. ), UNLOCK: Unlock this trinket by defeating Mother as Tainted Isaac, Causes Item rooms and Shops to appear in the Cathedral, UNLOCK: Unlock this trinket by defeating Isaac, ?? Your blood naturally clots so you don't lose too much blood if you are injured. It can only be fired after a short charge-up period (approximately 1-2 seconds until Isaac's head begins flashing red). Will take red hearts first before any other, Eve starts with this item after donating 439 coins to the Greed Donation Machine, UNLOCK: Unlock this item by beating Satan with Eve, Item Pool: Item Room, Curse Room, Demon Beggar, * devil pool, devil room pool, devil deal, the lost item pool, starting, silver, grey, gray, Upon use, this item refreshes the current floor with brand new rooms, monsters and items, as if you had entered a new floor, UNLOCK: Unlock this item by beating Satan with Blue Baby, Item Pool: Item Room, Secret Room, Devil Room, Demon Beggar, * secret room pool, item room, treasure room, item room pool, pill, tablet, drug, white, 111 will tell you what to do. Binding of Isaac: Rebirth Wiki is a FANDOM Games Community. Can be used with Placebo to generate infinite batteries, Amnesia - Hides the floor map for the rest of the current floor (same as curse of the lost). REPENTANCE - Skatole now prevents damage from eternal flies and Hush flies. While in a regular room, the chances to spawn a Red Room are: 1 Key = 33.33% chance. If it touches an enemy it breaks and leave a pool on the floor which freezes enemies and deals 8 damage per tick, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Items While in a Red room, the chances to spawn a Red Room are: 1 Key = 12.5% chance. ?, Satan and The Lamb as Tainted Keeper, While held, you will be teleported to a random room everytime you pick up a coin, UNLOCK: Unlock this trinket by defeating Mother as Tainted Keeper, Allows you to pay for a devil deal with this trinket, UNLOCK: Unlock this trinket by defeating Isaac, ?? The effect is weaker than normal runes. the lost item pool, grey, gray, A familiar which follows Isaac and shoots spectral tears that deal 3.5 damage, Ghost Baby fires tears at a rate of 1 tear per second, Can drop while destroying skulls in the Depths and Necropolis floors, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, white, spoopy, A spacebar item which allows Isaac to fire a blue flame that damages anything in its path for 23 damage per tick, Can cause up to a total of 276 potential damage, The flame destroys enemy shots, making it useful for bullet hell bosses, UNLOCK: Unlock this item by donating 900 coins to the Shop, * shop room pool, shop item pool, blue candle, grey, gray, silver, lamp, lantern, * boss room pool, boss room item, grey, gray, whip, cat o nine tails catonine tails, Upon use, re-rolls all pickup consumables in the current room into another random kind of pickup, This includes all types of pickup such as hearts, bombs, keys, coins, pills, tarot cards, chests, trinkets etc, UNLOCK: Unlock this item by beating the Chest with Isaac, * item room, treasure room, item room pool, dice pip, red, A familiar which follows Isaac and shoots two normal tears at once in a V-shaped pattern, Each of Harlequin Baby's tears deal 4 damage, Harlequin Baby fires tears at a rate of 1 tear per second, * item room, treasure room, item room pool, bug, eyes, pink, red, Tears now become missiles which deal huge damage to anything nearby, This item places a controllable red target on the ground which will cause a missile to fall from the sky and hit it after a short period of time, UNLOCK: Unlock this item by beating Challenge #19 (The Family Man), Item Pool: Secret Room Item Room (very low weight), * item room, treasure room, item room pool, fetus in a jar, bug, white, hat, pink, If a tear kills an enemy, it continues to travel forward with the leftover damage, * item room, treasure room, item room pool, large eye, cyclops, one eye, blue, white, A shadow follows Isaac and stomps on enemies randomly, dealing 40 damage per stomp (2 damage ticks at 20 damage each), * item room, treasure room, item room pool, white, yarn, wool, spider, Upon use, does 10 damage to all enemies in the room and gives them a slowing effect for 4 seconds, REPENTANCE - Enemies killed by Spider Butt will now spawn friendly blue spiders, * item room, treasure room, item room pool, brown, red, web, Gives Isaac an orbital knife that blocks shots and deals 15 damage per tick on contact with enemies, The highest damage orbital in the game, dealing 225 damage per second, Synergises very well with invulnerability items such as Book of Shadows, UNLOCK: Unlock this item by beating the Chest with Eve, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, bloody, smile, lil' brimstone, Prevents Isaac from taking any damage, but instead summons a familiar heart that follows you around. wickandskull. The damage formula of the bombs has changed from damage * 5 + 30 to damage * 10, UNLOCK: Unlock this item by beating Mom's Heart 9 times, * item room, treasure room, item room pool, baby, fetus, foetus, jar, white, pink, bug, dr fetus, Causes pickups on the floor move towards the player, Works across pits, but not through Key blocks, REPENTANCE - Magneto is now capable of opening chests from a small distance. A blood clot forms through several steps: The blood vessel narrows. Doors remain open when entering a room with enemies in it. ?, Soul of the Lost, 4 rooms: Rune of Ehwaz, Rune of Perthro, Black Rune, Soul of Isaac, Soul of Eve, Soul of Eden, Soul of the Forgotten, Soul of Jacob and Esau, 6 rooms: Rune of Dagaz, Soul of Samson, Soul of Azazel, Soul of Apollyon, Soul of Bethany, 12 rooms: Rune of Jera, Soul of Lilith, Soul of the Keeper, Tears have a chance to fire a fungus tear that sticks to enemies. On average . - Destroys all poops in the room and spawns a blue attack spider on every destroyed poop, Infested? The priority list of what will drop from champion enemies in order is as follows: Soul Hearts - When you have no red heart containers and less than 2 soul hearts, Red Hearts (Full hearts) - While at 0.5 red hearts, Red Hearts (Full hearts) - When you have at least half a red heart container empty, Trinkets - If you have no trinkets and there are no trinkets on the ground in the room, Soul Hearts - When you have less than 6 total heart containers of any kind, If none of the above conditions are true, champions will resume dropping their regular pickups, UNLOCK: Unlock this item by defeating Greedier mode with Maggy, Allows you to fire tears diagonally by holding down two of the fire buttons at once, If you are using a gamepad, this item allows you to fire in any direction, The first enemy you kill in each new room will now explode and poison all nearby enemies, causing them to take periodic damage until they also die and explode, If you have lots of enemies near each other this can cause a chain reaction, killing lots of enemies in one go, Gives Isaac a finger which floats infront of him and points in the same direction he is facing or firing. Curses Little Gish Little Steve The Relic The Halo Money Equals Power Blood Bag Odd Mushroom (Thin) Odd Mushroom (Large) Whore Of Babylon Bucket Of Lard Curses Abel, UNLOCK: Unlock this trinket by defeating Isaac, ?? This gives Isaac a bone sword and he goes on a killing rampage, gaining +0.4 Speed, +3 Flat Damage Up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Samson, Activates the Mega Blast item effect, which gives you a giant laser that deals x5 your tear damage per tick to anything in its path and pushing Isaac back by the force, The effect lasts for 8 seconds but does persist between rooms, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Azazel, When used this kills Isaac and revives him with 1/2 a red heart. Keys and bombs are equal to 3 coins for deciding which to give, Item Pool: Boss Room, Golden Chest, Crane Game, Grants a large orbital that rotates around Isaac, When the orbital takes a few hits, they split into two smaller ones, After the smaller orbitals take another hit, they explode into 2 blue spiders, This item will respawn after a period of time, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Lazarus, Your bombs now explode and fire 4 Brimstone lasers in all cardinal directions, Each brimstone laser deals 8 damage per tick for 13 total hits, UNLOCK: Unlock this item by killing Hornfel before he can escape after breaking his minecart, Item Pool: Devil Room, Bomb Beggar, Greed Mode Devil Room, Active items no longer charge up as normal from clearing rooms, Enemies taking damage now charges your item instead. The Binding of Isaac: Rebirth has been updated to version 1.7.5 today by Nicalis. Once you've beaten Mother once, a door will appear at the starting room in Depths II, which leads to the Mausoleum/Gehenna floors. If combined with My Reflection, the beam will first wrap around Isaac, form an oval beam in a longer range, then shoot backward. Challenges After a few seconds, the crosshair will disappear, and the Ghost will do certain things based on what you targeted: Items, pickups, trinkets: Brings them to Isaac. cash money, When used, Isaac gains homing shots and +3.0 Range Up for the current room, Counts as 1 of 3 book items needed towards the Bookworm transormation, * library pool, library room, book room pool, item room, treasure room, item room pool, UNLOCK: Unlock this item by beating Greed Mode with ??? This doesn't convert hearts that dropped before picking up this trinket, and doesn't apply to set heart drops, i.e. This item was awarded in Genuine quality to players who purchased The Binding of Isaac . REPENTANCE - This item was completely reworked for Repentance and no longer forces a random dice use each time. This video showcases all blood clot familiar variants that can be created with the Sumptorium item in The Binding of Isaac Repentance. Blood Clot doesn't work with Lilith since she . Chapters Blood Bag) it will be rerolled into a random Item Room item, Cannot remove Azazel's Brimstone laser, or The Lost's Holy Mantle, REPENTANCE - Full run reroll effects are now able to remove heart containers and transformations if losing the respective items during the reroll, UNLOCK: Unlock this item by blowing up 30 slot machines, * item room, treasure room, item room pool, dice pip, starting, pyramid, green, triange, When used, 'devolves' all enemies in the room which are currently alive into another weaker type of enemy, * item room, treasure room, item room pool, DIO, dice pip, orange, brown, turban, When used, copies the effect of the card you are currently holding without consuming it, The charge time of this item depends on the quality of the card you're holding, Using this with the ? Synergy that applies to Chemical Peel also applies to Chemical Peel also applies to Chemical Peel also applies blood. 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